Modeling P2Y receptor–Ca2+ response coupling in taste cells
نویسندگان
چکیده
منابع مشابه
Calcium signaling mediated by P2Y receptors in mouse taste cells.
Evidence implicates a number of neuroactive substances and their receptors in mediating complex cell-to-cell communications in the taste bud. Recently, we found that ATP, a ubiquitous neurotransmitter/neuromodulator, mobilizes intracellular Ca2+ in taste cells by activating P2Y receptors. Here, P2Y receptor-cellular response coupling was characterized in detail using single cell ratio photometr...
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Rat brain capillary endothelial (B10) cells express an unidentified nucleotide receptor linked to adenylyl cyclase inhibition. We show that this receptor in B10 cells is identical in sequence to the P2Y(12) ADP receptor ("P2Y(T)") of platelets. When expressed heterologously, 2-methylthio-ADP (2-MeSADP; EC(50), 2 nm), ADP, and adenosine 5'-O-(2-thio)diphosphate were agonists of cAMP decrease, an...
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Abstract: The governing equations of motion for a drill string considering coupling between axial, lateral and torsional vibrations are obtained using a Lagrangian approach. The result leads to a set of non-linear equations with time varying coefficients. A fully coupled model for axial, lateral, and torsional vibrations of drill strings is presented. The bit/formation interactions are assumed ...
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PURPOSE The objectives of this study were to evaluate the potential release of ATP that is mediated by mechanical stress on trabecular meshwork (TM) cells, to identify the specific P2Y receptors mediating the ATP response, and to determine whether cellular senescence might interfere with the P2Y receptor-mediated calcium response, thus contributing to the loss of physiologic TM function in agin...
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The number of basic taste qualities registered by single human fungiform papillae is correlated with the number of taste buds borne on these papillae. Multiple sensitivity was demonstrated both in single fungiform papillae and in single taste buds, with response to all four of the basic taste qualities occuring in a single taste bud.
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Biomembranes
سال: 2007
ISSN: 0005-2736
DOI: 10.1016/j.bbamem.2007.04.002